OptiMap System

OptiMap System

See What Matters
01/ See AF Differently02/ Visualize03/ Personalize04/ Optimize05/ Electrographic Flow 06/ Testimonials 07/ Contact us 08/ References

See AF Differently

Cortex aims to transform the diagnosis and treatment of atrial arrhythmias by providing insight into each individual patient’s disease pathophysiology.

The OptiMap™ System is a 510(k) cleared, electrographic flow (EGF) mapping solution designed with AI, enabling physicians to See What Matters.



The OptiMap™ System is a 510(k) cleared, advanced mapping system that calculates Electrographic Flow™ (EGF) from a single minute of unipolar electrogram signals recorded from the 64-electrode OptiMap™ basket catheter. Our software uses an innovative optical flow algorithm to enable the full spatiotemporal reconstruction of the otherwise chaotic and disorganized electrical conduction of atrial fibrillation—allowing you to See What Matters.1,2



For each individual patient, the EGF algorithm provides vector flow estimations that identify active sources as divergent excitation waves that may represent triggers or drivers of atrial arrhythmias outside the pulmonary veins3 and the consistency of wavefront propagation may be indicative of atrial substrate.* Understanding the pathophysiologic mechanisms contributing to a particular patient’s atrial fibrillation is the key to improving treatment effectiveness.4,5



For patients with challenging and complex atrial arrhythmias, PVI is not enough and a one-size-fits-all anatomical approach risks both failing to ablate critical triggers/drivers and over-ablating areas of heart tissue that are not playing a role in the pathophysiology of an individual patient’s disease.6 The ability to phenotype AF patients may facilitate the customization of a focused, minimal ablation strategy requiring the least amount of ablative tissue destruction while optimizing clinical success.5,6,7


Electrographic Flow

A visualization of how EGF mapping takes a single minute of unipolar electrogram signals recorded from the 64-electrode OptiMap™ Catheter and uses an innovative optical flow algorithm to reconstruct the chaotic and disorganized electrical conduction of atrial fibrillation.

Cortex aims to leverage the latest in what’s possible with multimodal AI in medtech to drive new technologies and impact patient outcomes.
Dr. Matt Lungren
Chief Data Science Officer for Microsoft Health & Life Sciences
The Cortex OptiMap System fits neatly into my workflow. I appreciated the simplicity of the system and the insight it provides during complex redo AF cases.
Dr. Wilber Su
Director of Cardiac Electrophysiology at Banner-University Medical Center and Professor of Medicine at the University of Arizona
Having used the OptiMap System in multiple cases, I’m impressed by the technology. It has the potential to provide a much-needed solution for identifying extra-pulmonary vein sources of AF.
Dr. Nishaki Mehta
Associate Professor at Beaumont Health Department of Cardiovascular Medicine, Oakland University William Beaumont School of Medicine

Contact Us

Reach out to learn more about the Cortex OptiMap System.


  1. Haines DE, Kong MH, Ruppersberg P, Haeusser P, Avitall B, Szili-Torok T, Verma A. Electrographic flow mapping for atrial fibrillation: theoretical basis and preliminary observations. Journal of Interventional Cardiac Electrophysiology 2023;66(4):1015-1028.
  2. Kong MH,  Castellano S, Ruppersberg P, Lizama KS, Avitall B. Visualization of electrographic flow fields of increasing complexity and detection of simulated sources during spontaneously persistent AF in an animal model. Front Cardiovasc Med 2023. doi: 10.3389/fcvm.2023.1223481.
  3. Bellmann B, Lin T, Ruppersberg P, Zettwitz M, Guttmann S, Tscholl V, Nagel P, Roser M, Landmesser U, Rillig A. Identification of active atrial fibrillation sources and their discrimination from passive rotors using electrographic flow mapping. Clin Res Cardiol 2018;107(11):1021-1032.
  4. Reddy VY, Castellano S, Szili-Torok T, Petru J, Funasako M, Hoogendijk M, Wijchers S, Spitzer SG, Rillig A, Neuzil P, Kong MH. Phenotyping persistent atrial fibrillation with electrographic flow mapping. Heart Rhythm 2023;20(5S):S184-185.
  5. Szili-Torok T, Neuzil P, Langbein A, Petru J, Funasako M, Dinshaw L, Wijchers S, Bhagwandien R, Rillig A, Spitzer SG, Metzner A, Kong MH, Reddy VY. Electrographic flow-guided ablation in Redo patients with persistent atrial fibrillation (FLOW-AF): design and rationale. Heart Rhythm O2 2023;1-10.
  6. Gagyi R, Bhagwandien R, Yap SC, Hoogendijk M, Wijchers S, Szili-Torok T. Electrographic flow mapping guided catheter ablation offers advantages for patients with persistent atrial fibrillation. Pacing Clinical Electrophysiol 2023;1-11.
  7. Reddy VY, Langbein A, Petru J, et. al. A Randomized Trial of Electrographic Flow-Guided Ablation During Redo Procedures for Non-Paroxysmal Atrial Fibrillation (FLOW-AF). JACC EP 2024.